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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1885 1
1892 1
1907 1
1908 1
1910 1
1936 1
1941 1
1946 1
1948 3
1951 1
1954 1
1956 2
1958 1
1959 1
1960 4
1961 2
1962 3
1963 4
1964 3
1965 5
1966 6
1967 10
1968 7
1969 7
1970 10
1971 6
1972 8
1973 5
1974 10
1975 48
1976 61
1977 51
1978 48
1979 58
1980 80
1981 92
1982 137
1983 152
1984 192
1985 170
1986 197
1987 240
1988 226
1989 256
1990 249
1991 258
1992 287
1993 283
1994 302
1995 358
1996 357
1997 371
1998 418
1999 418
2000 428
2001 439
2002 409
2003 478
2004 589
2005 580
2006 589
2007 560
2008 564
2009 657
2010 688
2011 802
2012 864
2013 867
2014 976
2015 966
2016 1055
2017 1078
2018 1139
2019 1189
2020 1328
2021 1481
2022 1439
2023 1246
2024 623

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24,121 results

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Page 1
The Relationship Between Vancomycin Trough Concentrations and AUC/MIC Ratios in Pediatric Patients: A Qualitative Systematic Review.
Tkachuk S, Collins K, Ensom MHH. Tkachuk S, et al. Paediatr Drugs. 2018 Apr;20(2):153-164. doi: 10.1007/s40272-018-0282-4. Paediatr Drugs. 2018. PMID: 29344778 Review.
One study in patients undergoing cardiothoracic surgery found a trough of 18.4 mg/l achieved an AUC/MIC > 400. Two oncology studies reported troughs 15 mg/l likely attained an AUC/MIC 400. ...For MIC 2 mg/l, higher troughs are likely necessary to achieve a …
One study in patients undergoing cardiothoracic surgery found a trough of 18.4 mg/l achieved an AUC/MIC > 400. Two oncology studie …
Determinants of Vancomycin Trough Concentration in Patients Receiving Continuous Veno-Venous Hemodialysis.
Quinn NJ, Sacha GL, Wanek MR, Yerke J, Srinivas P, Hohlfelder B. Quinn NJ, et al. Ann Pharmacother. 2022 Oct;56(10):1133-1138. doi: 10.1177/10600280211073370. Epub 2022 Feb 8. Ann Pharmacother. 2022. PMID: 35130750
RESULTS: A total of 160 patients were included. The median vancomycin dose was 12.6 mg/kg with a trough of 24.6 mcg/mL. Weight, 24-hour UOP, vancomycin dose (mg/kg), and dialysate rate (mL/kg/h) were all determined to be independent predictors of vancomycin trough l …
RESULTS: A total of 160 patients were included. The median vancomycin dose was 12.6 mg/kg with a trough of 24.6 mcg/mL. Weight, 24-ho …
Mycophenolic acid trough level monitoring in solid organ transplant recipients treated with mycophenolate mofetil: association with clinical outcome.
Kaplan B. Kaplan B. Curr Med Res Opin. 2006 Dec;22(12):2355-64. doi: 10.1185/030079906X148481. Curr Med Res Opin. 2006. PMID: 17257450 Review.
Based on current evidence, the adherence to presently recommended target ranges for MPA troughs in solid organ transplantation cannot assure an improved clinical outcome with MMF therapy. Whether MPA trough level monitoring leads to improved efficacy and less toxici …
Based on current evidence, the adherence to presently recommended target ranges for MPA troughs in solid organ transplantation cannot …
Crest to Trough Cellular Drifting of Green-Synthesized Zinc Oxide and Silver Nanoparticles.
Hasan M, Zafar A, Imran M, Iqbal KJ, Tariq T, Iqbal J, Shaheen A, Hussain R, Anjum SI, Shu X. Hasan M, et al. ACS Omega. 2022 Sep 20;7(39):34770-34778. doi: 10.1021/acsomega.2c02178. eCollection 2022 Oct 4. ACS Omega. 2022. PMID: 36211074 Free PMC article.
The well-characterized NPs with an average size of 35 nm (ZnO) and 25 nm (Ag) were functionalized on the cresty plates for antibacterial inhibition against Staphylococcus aureus and Pseudomonas aeruginosa, with the flowerlike ZnONPs exhibiting 90.9% inhibition and AgNPs exhibitin …
The well-characterized NPs with an average size of 35 nm (ZnO) and 25 nm (Ag) were functionalized on the cresty plates for antibacterial inh …
Rethinking Movement Disorders.
Münchau A, Klein C, Beste C. Münchau A, et al. Mov Disord. 2024 Mar;39(3):472-484. doi: 10.1002/mds.29706. Epub 2024 Jan 9. Mov Disord. 2024. PMID: 38196315 Review.
According to this concept, MDs can be understood as phenomena requiring and fostering flexible modifications of perception-action associations. Consequently, although conceived as being caught in a (trough) state of deficits, given their high flexibility, people with MDs a …
According to this concept, MDs can be understood as phenomena requiring and fostering flexible modifications of perception-action associatio …
Water-absorption-trough dewatering machine for estimation of organic carbon in moist soil.
Lin L, Wang Y, Liu X, Zhang X. Lin L, et al. Environ Pollut. 2021 Sep 1;284:117445. doi: 10.1016/j.envpol.2021.117445. Epub 2021 May 26. Environ Pollut. 2021. PMID: 34062429
In this study, we proposed a new deep learning algorithm named the Water Absorption Trough Dewatering Machine (WATDM) to improve estimations of SOC from soil reflectance spectra and reduce the effect of soil water. ...Based on the soil water contents derived from the water …
In this study, we proposed a new deep learning algorithm named the Water Absorption Trough Dewatering Machine (WATDM) to improve esti …
The Impact of Rivaroxaban and Apixaban on Tacrolimus Trough Levels.
Scheibner AC, Franco-Martinez C, Kincaide E, Hall R, Long C. Scheibner AC, et al. Prog Transplant. 2021 Sep;31(3):236-241. doi: 10.1177/15269248211024601. Epub 2021 Jun 22. Prog Transplant. 2021. PMID: 34155947
This study aimed to clarify the impact of rivaroxaban/apixaban on tacrolimus troughs. Fifty solid organ transplant recipients with concomitant use of tacrolimus and rivaroxaban/apixaban were retrospectively assessed for changes in tacrolimus troughs and dose. Averag …
This study aimed to clarify the impact of rivaroxaban/apixaban on tacrolimus troughs. Fifty solid organ transplant recipients with co …
Outpatient vancomycin therapy: Acute kidney injury in individualized AUC-based goal trough ranges versus traditional trough dosing.
Rees MR, Carr DR, Trienski T, Buchanan C, White K, Bremmer DN. Rees MR, et al. J Am Pharm Assoc (2003). 2022 May-Jun;62(3):706-710. doi: 10.1016/j.japh.2021.11.031. Epub 2021 Dec 1. J Am Pharm Assoc (2003). 2022. PMID: 34920955
OBJECTIVE: The purpose of this study was to assess the incidence of AKI in patients receiving vancomycin dosed by AUC-based goal troughs and vancomycin dosed by traditional trough goals (15-20 mcg/mL) in the outpatient setting. ...Secondary objectives included asses …
OBJECTIVE: The purpose of this study was to assess the incidence of AKI in patients receiving vancomycin dosed by AUC-based goal troughs …
Vancomycin area under the curves estimated with pharmacokinetic equations using trough-only data.
Fewel N. Fewel N. J Clin Pharm Ther. 2021 Oct;46(5):1426-1432. doi: 10.1111/jcpt.13474. Epub 2021 Jun 25. J Clin Pharm Ther. 2021. PMID: 34169543 Free PMC article. Clinical Trial.
The most practical way to perform AUC-guided dosing is by estimating an AUC from a steady-state trough. The purpose of this study was to compare AUCs estimated from trough-only data to AUCs calculated from peak and trough concentrations. ...Patients were incl …
The most practical way to perform AUC-guided dosing is by estimating an AUC from a steady-state trough. The purpose of this study was …
Evaluation of a trough-only extrapolated area under the curve vancomycin dosing method on clinical outcomes.
Lines J, Burchette J, Kullab SM, Lewis P. Lines J, et al. Int J Clin Pharm. 2021 Feb;43(1):263-269. doi: 10.1007/s11096-020-01157-3. Epub 2020 Sep 23. Int J Clin Pharm. 2021. PMID: 32964405
Background Vancomycin dosing strategies targeting trough concentrations of 15-20 mg/L are no longer supported due to lack of efficacy evidence and increased risk of nephrotoxicity. Area-under-the-curve (AUC(24)) nomograms have demonstrated adequate attainment of AUC(24) go …
Background Vancomycin dosing strategies targeting trough concentrations of 15-20 mg/L are no longer supported due to lack of efficacy …
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